Generally, depression does not result from a single event, but from a combination of recent events and other longer-term or personal factors. Ongoing difficulties such as long-term unemployment, living in an uncaring relationship, loneliness, and continued exposure to stress at work are likely causes of depression. Personal factors such as your family history, your personality, serious medical illness or drug and alcohol use also play a role. Talk therapy will work through these issues and empower you to take control of negative thoughts and feelings which imapact your mood and hold you back.